NEUROMUSCULAR BLOCKING PROPERTIES OF STEREOISOMERIC ANDROSTANE-3, 17-BISQUATERNARY AMMONIUM SALTS
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Bile salts and neuromuscular blocking agents.
The influence of the primary bile salts taurocholate and chenodeoxycholate on the neuromuscular blockade of the non-depolarizing drugs Org 6368, pancuronium, Org NC 45 and hexafluorenium was studied in cats. An increase in the effects of these agents, all possessing widely varying molecular structures, was found following administration of the bile salts. The bile salt concentrations in plasma ...
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In 1916 Jacobs, Heidelberger, and coworkers at the Rockefeller Institute reported the discovery of a new class of synthetic compounds which possessed potent bactelicidal properties. By reacting hexamethylenetetramine with a large variety of substituted benzylor alkyl-halides, nujmerous quaternary salts of this base were obtained. It was observed that most of these salts had pronounced bacterici...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology and Chemotherapy
سال: 1967
ISSN: 0366-0826
DOI: 10.1111/j.1476-5381.1967.tb02125.x